Geneviève Calame was born in Geneva of Greco-Italian ancestry, and studied the piano in Geneva with Lottie Morel and then in Rome with Guido Agosti. She continued her education in Geneva with Louis Hiltbrand and Jacques Guyonnet. She took further courses in composition in London with Pierre Boulez, in Liège with Henri Pousseur and in Paris with Jean-Claude Eloy. She appeared as a piano soloist many times un the Studio de Musique Contenporaine from 1972 to 1983. She studied electronic and electro-acoustic technology in New York City with Hubert Howe and visual artist Bill Etra.
After completing her education, Geneviève Calame worked as a composer through contemporary music studios in Geneva. In 1971 she and Jacques Guyonnet founded a studio for electronic music, video and
Geneviève Calame developed a method for teaching electronic music to children and taught from 1975-1993 at the Geneva's Board of Education and in l'Ecole Supérieure d'Art Visuel in Geneva. In 1976 she served as president of the Geneva section of the International Society of Contemporary Music. She was a leader in Video Art, producing more than hundred paintings from video still frames. This work was presented in Cannes at the MIP TV and many places around the world, A.R.T. Studios Geneva, Museum of fine ARTS in Lausanne with René Berger, Rio de Janeiro at Cecilia Meireles and the Serpentine Gallery in London among others.